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What is a genetic contribution to the development of the most common forms of atherosclerosis?

What is a genetic contribution to the development of the most common forms of atherosclerosis?

The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification.

What term is used to describe the gene to gene interaction in which the action of one gene modifies the expression of a different gene?

Whether or not they are sorting independently, genes may interact at the level of gene products such that the expression of an allele for one gene masks or modifies the expression of an allele for a different gene. This is called epistasis.

What gene is associated with stroke?

They identified a new gene called FOXF2 which increased the risk of having a stroke due to small vessel disease in the brain.

What is the impact of genetic predisposition to disease on disease risk?

Increased likelihood or chance of developing a particular disease due to the presence of one or more gene mutations and/or a family history that indicates an increased risk of the disease.

Which lysosomal storage disease is associated with an increased risk for stroke?

Fabry disease An x-linked lysosomal storage disease, due to deficiency of a lysosomal hydrolase (alpha galactosidase A). Accumulation of GAGs (glycotriosylceramide) in lysosomes of cells including vascular endothelium leads to vessel occlusion and strokes [11]. It can affect both small and large vessels.

What is the most common genetic cardiac disorder worldwide?

Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide and may have serious cardiovascular health consequences. AF is associated with increased risk of stroke, dementia, heart failure, and death.

What are the types of gene interaction?

Various types of epistatic gene interaction are 1) Recessive epitasis (9:3:4) 2) Dominant epistasis (12:3:1) 3) Dominant and recessive (inhibitory) epistasis (13:3) 4) Duplicate recessive epistasis (9:7) 5) Duplicate dominant epistasis (15:1) and 6) Polymeric gene interaction (9:6:1).

What do you mean by gene interaction?

Genetic interaction is the set of functional association between genes. One such relationship is epistasis, which is the interaction of non-allelic genes where the effect of one gene is masked by another gene to result either in the suppression of the effect or they both combine to produce a new trait (character).

Why is age a risk factor for stroke?

Main risk factors for stroke As we get older, our arteries naturally become narrower and harder. They are also more likely to become clogged with fatty material, known as atherosclerosis.

Can strokes be prevented?

The best way to help prevent a stroke is to eat a healthy diet, exercise regularly, and avoid smoking and drinking too much alcohol. These lifestyle changes can reduce your risk of problems like: arteries becoming clogged with fatty substances (atherosclerosis) high blood pressure.

What are two environmental factors that are likely to affect gene expression?

In addition to drugs and chemicals, temperature and light are external environmental factors that may influence gene expression in certain organisms.

How do genetic factors affect health and wellbeing?

Changes in many genes, each with a small effect, may underlie susceptibility to many common diseases, including cancer, obesity, diabetes, heart disease, and mental illness.

Can a stroke be due to a hereditary condition?

Many of these conditions are hereditary, meaning they are passed down through family lines. Diagnosis of a stroke due to a hereditary or rare condition usually begins with a physical exam and a detailed review of the patient’s medical history and symptoms.

What are the risk factors for a stroke?

However, some factors cannot be controlled. In younger individuals, the risk of having a stroke is low. However, as people age, the risk increases. If a person has a family history of various medical conditions that can contribute to stroke, then they will be at more risk of experiencing a stroke.

How are comorbidities delay the diagnosis of stroke?

B. Comorbidities mask the symptoms and delay the diagnosis. C. Environmental risk factors have equal contribution to the problem. D. Often the person with a stroke cannot provide accurate family information

Why do people think stroke can be passed down?

The reason why people think that strokes can be passed down is that there are some risk factors for stroke that are hereditary. Examples of these are high blood pressure, high cholesterol or diabetes. These medical conditions can be passed down within a family and they can also increase the risk of stroke.